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Glucocorticoid causes iron accumulation in liver byup-regulating expression of iron regulatory protein 1 gene through GR and STAT 5. Expiratory time is the time allowed between inspirations. Diabetics noted improvements in glucose control, and asthmat-ics had fewer attacks and significantly improved pulmonary function tests.Field noted decreases in cortisol and catecholamine levels, and she pos-tulated increased parasympathetic activity as an underlying mechanismfor changes
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Long-term treatment is based on the concept that remainingbacteria cannot be killed by host defense, if the microorganisms persist as biofilm.Therefore, we suggest a 3-month course in case of debridement with implant retention,one-stage exchange, or two-stage exchange with a short interval (2–3 weeks) [30, 47, 48].For knee PJI, even a 6-month course is suggested [30, 47, 49].
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